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1

Structure–activity relationship study of [1,2,3]thiadiazole necroptosis inhibitors

Xin Teng, Heather Keys, Arumugasamy Jeevanandam, John A. Porco Jr., Alexei Degterev, Junying Yuan, Gregory D. Cuny

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 151 KB

english, 2007

2

A novel tracing algorithm for high throughput imaging: Screening of neuron-based assays

Yong Zhang, Xiaobo Zhou, Alexei Degterev, Marta Lipinski, Donald Adjeroh, Junying Yuan, Stephen T.C. Wong

Journal:

Journal of Neuroscience Methods

Year:

2007

Language:

english

File:

PDF, 2.80 MB

english, 2007

3

Expression and purification of active receptor interacting protein 1 kinase using a baculovirus system

Maki, Jenny L., Tres Brazell, J., Teng, Xin, Cuny, Gregory D., Degterev, Alexei

Journal:

Protein Expression and Purification

Year:

2013

Language:

english

File:

PDF, 821 KB

english, 2013

4

Targeting RIPK1 for the treatment of human diseases

Degterev, Alexei, Ofengeim, Dimitry, Yuan, Junying

Journal:

Proceedings of the National Academy of Sciences

Year:

2019

File:

PDF, 1.08 MB

2019

5

Automated neurite labeling and analysis in fluorescence microscopy images

Guanglei Xiong, Xiaobo Zhou, Alexei Degterev, Liang Ji, Stephen T. C. Wong

Journal:

Cytometry Part A

Year:

2006

Language:

english

File:

PDF, 1006 KB

english, 2006

6

A Combined Experimental and Density Functional Theory Study on the Pd-Mediated Cycloisomerization of o-Alkynylnitrobenzenes – Synthesis of Isatogens and Their Evaluation as Modulators of ROS-Mediated Cell Death

Chepuri V. Ramana, Pitambar Patel, Kumar Vanka, Benchun Miao, Alexei Degterev

Journal:

European Journal of Organic Chemistry

Year:

2010

Language:

english

File:

PDF, 1.02 MB

english, 2010

7

A Combined Experimental and Density Functional Theory Study on the Pd-Mediated Cycloisomerization of o-Alkynylnitrobenzenes – Synthesis of Isatogens and Their Evaluation as Modulators of ROS-Mediated Cell Death (Eur. J. Org. Chem. 31/2010)

Chepuri V. Ramana, Pitambar Patel, Kumar Vanka, Benchun Miao, Alexei Degterev

Journal:

European Journal of Organic Chemistry

Year:

2010

Language:

english

File:

PDF, 572 KB

english, 2010

8

Necroptosis, a novel form of caspase-independent cell death, contributes to neuronal damage in a retinal ischemia-reperfusion injury model

Daniel M. Rosenbaum, Alexei Degterev, Joel David, Pearl S. Rosenbaum, Steven Roth, James C. Grotta, Gregory D. Cuny, Junying Yuan, Sean I. Savitz

Journal:

Journal of Neuroscience Research

Year:

2010

Language:

english

File:

PDF, 617 KB

english, 2010

9

Structure–activity relationship study of novel necroptosis inhibitors

Xin Teng, Alexei Degterev, Prakash Jagtap, Xuechao Xing, Sungwoon Choi, Régine Denu, Junying Yuan, Gregory D. Cuny

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 153 KB

english, 2005

10

Structure–activity relationship analysis of a novel necroptosis inhibitor, Necrostatin-5

Ke Wang, Jinfeng Li, Alexei Degterev, Emily Hsu, Junying Yuan, Chengye Yuan

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 208 KB

english, 2007

11

Structure–activity relationship and liver microsome stability studies of pyrrole necroptosis inhibitors

Xin Teng, Heather Keys, Junying Yuan, Alexei Degterev, Gregory D. Cuny

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 160 KB

english, 2008

12

Structure–activity relationship study of a novel necroptosis inhibitor, necrostatin-7

Weihong Zheng, Alexei Degterev, Emily Hsu, Junying Yuan, Chengye Yuan

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 182 KB

english, 2008

13

A HPLC method for the quantitative determination of N-(2-hydroxy-5-nitrophenylcarbamothioyl)-3,5-dimethylbenzamide in biological samples

Igor Skidan, Jacob Grunwald, Ritesh Thekkedath, Alexei Degterev, Vladimir Torchilin

Journal:

Journal of Chromatography B

Year:

2011

Language:

english

File:

PDF, 502 KB

english, 2011

14

A computational framework for studying neuron morphology from in vitro high content neuron-based screening

Yue Huang, Xiaobo Zhou, Benchun Miao, Marta Lipinski, Yong Zhang, Fuhai Li, Alexei Degterev, Junying Yuan, Guangshu Hu, Stephen T.C. Wong

Journal:

Journal of Neuroscience Methods

Year:

2010

Language:

english

File:

PDF, 953 KB

english, 2010

15

10.1038/14712

Degterev, Alexei, Yuan, Junying

Journal:

Nature Neuroscience

Year:

1999

Language:

english

File:

PDF, 114 KB

english, 1999

16

10.1038/35055085

Degterev, Alexei, Lugovskoy, Alexey, Cardone, Michael, Mulley, Bradley, Wagner, Gerhard, Mitchison, Timothy, Yuan, Junying

Journal:

Nature Cell Biology

Year:

2001

Language:

english

File:

PDF, 817 KB

english, 2001

17

Necrostatin-1 reduces histopathology and improves functional outcome after controlled cortical impact in mice

You, Zerong, Savitz, Sean I, Yang, Jinsheng, Degterev, Alexei, Yuan, Junying, Cuny, Gregory D, Moskowitz, Michael A, Whalen, Michael J

Journal:

Journal of Cerebral Blood Flow and Metabolism

Year:

2008

Language:

english

File:

PDF, 306 KB

english, 2008

18

Identification of RIP1 kinase as a specific cellular target of necrostatins

Degterev, Alexei, Hitomi, Junichi, Germscheid, Megan, Ch'en, Irene L, Korkina, Olga, Teng, Xin, Abbott, Derek, Cuny, Gregory D, Yuan, Chengye, Wagner, Gerhard

Journal:

Nature Chemical Biology

Year:

2008

Language:

english

File:

PDF, 531 KB

english, 2008

19

Corrigendum: Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury

Degterev, Alexei, Huang, Zhihong, Boyce, Michael, Li, Yaqiao, Jagtap, Prakash, Mizushima, Noboru, Cuny, Gregory D, Mitchison, Timothy J, Moskowitz, Michael A, Yuan, Junying

Journal:

Nature Chemical Biology

Year:

2005

Language:

english

File:

PDF, 47 KB

english, 2005

20

Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury

Degterev, Alexei, Huang, Zhihong, Boyce, Michael, Li, Yaqiao, Jagtap, Prakash, Mizushima, Noboru, Cuny, Gregory D, Mitchison, Timothy J, Moskowitz, Michael A, Yuan, Junying

Journal:

Nature Chemical Biology

Year:

2005

Language:

english

File:

PDF, 509 KB

english, 2005

21

Expansion and evolution of cell death programmes

Degterev, Alexei, Yuan, Junying

Journal:

Nature Reviews Molecular Cell Biology

Year:

2008

Language:

english

File:

PDF, 686 KB

english, 2008

22

A decade of caspases

Degterev, Alexei, Boyce, Michael, Yuan, Junying

Journal:

Year:

2003

Language:

english

File:

PDF, 462 KB

english, 2003

23

Fluorescence polarization assay for inhibitors of the kinase domain of receptor interacting protein 1

Jenny L. Maki, Elizabeth E. Smith, Xin Teng, Soumya S. Ray, Gregory D. Cuny, Alexei Degterev

Journal:

Analytical Biochemistry

Year:

2012

Language:

english

File:

PDF, 1.56 MB

english, 2012

24

Optimization of tricyclic Nec-3 necroptosis inhibitors for in vitro liver microsomal stability

Sungwoon Choi, Heather Keys, Richard J. Staples, Junying Yuan, Alexei Degterev, Gregory D. Cuny

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 519 KB

english, 2012

25

Small-Molecule Inhibition of the Interaction between the Translation Initiation Factors eIF4E and eIF4G

Nathan J. Moerke, Huseyin Aktas, Han Chen, Sonia Cantel, Mikhail Y. Reibarkh, Amr Fahmy, John D. Gross, Alexei Degterev, Junying Yuan, Michael Chorev, Jose A. Halperin, Gerhard Wagner

Journal:

Year:

2007

Language:

english

File:

PDF, 700 KB

english, 2007

26

Identification of a Molecular Signaling Network that Regulates a Cellular Necrotic Cell Death Pathway

Junichi Hitomi, Dana E. Christofferson, Aylwin Ng, Jianhua Yao, Alexei Degterev, Ramnik J. Xavier, Junying Yuan

Journal:

Year:

2008

Language:

english

File:

PDF, 1.86 MB

english, 2008

27

Diversity in the Mechanisms of Neuronal Cell Death

Junying Yuan, Marta Lipinski, Alexei Degterev

Journal:

Year:

2003

Language:

english

File:

PDF, 262 KB

english, 2003

28

The role of NF-1 factors in regulation of elastin gene transcription

Alexei Degterev, Judith A. Foster

Journal:

Year:

1999

Language:

english

File:

PDF, 1.75 MB

english, 1999

29

Automated neurite extraction using dynamic programming for high-throughput screening of neuron-based assays

Yong Zhang, Xiaobo Zhou, Alexei Degterev, Marta Lipinski, Donald Adjeroh, Junying Yuan, Stephen T.C. Wong

Journal:

Year:

2007

Language:

english

File:

PDF, 2.56 MB

english, 2007

30

Micellar formulations of pro-apoptotic DM-PIT-1 analogs and TRAIL in vitro and in vivo

Riehle, Robert D., Cornea, Sinziana, Degterev, Alexei, Torchilin, Vladimir

Journal:

Year:

2013

Language:

english

File:

PDF, 2.23 MB

english, 2013

31

Structure−Activity Relationship Study of Tricyclic Necroptosis Inhibitors

Jagtap, Prakash G., Degterev, Alexei, Choi, Sungwoon, Keys, Heather, Yuan, Junying, Cuny, Gregory D.

Journal:

Journal of Medicinal Chemistry

Year:

2007

Language:

english

File:

PDF, 185 KB

english, 2007

32

Structural Basis of RIP1 Inhibition by Necrostatins

Xie, Tian, Peng, Wei, Liu, Yexing, Yan, Chuangye, Maki, Jenny, Degterev, Alexei, Yuan, Junying, Shi, Yigong

Journal:

Year:

2013

Language:

english

File:

PDF, 887 KB

english, 2013

33

Retinal ganglion cell (RGC) programmed necrosis contributes to ischemia–reperfusion-induced retinal damage

Dvoriantchikova, Galina, Degterev, Alexei, Ivanov, Dmitry

Journal:

Experimental Eye Research

Year:

2014

Language:

english

File:

PDF, 1.87 MB

english, 2014

34

[Methods in Enzymology] Regulated Cell Death Part B - Necroptotic, Autophagic and other Non-apoptotic Mechanisms Volume 545 || Assays for Necroptosis and Activity of RIP Kinases

Degterev, Alexei

Year:

2014

Language:

english

File:

PDF, 1.12 MB

english, 2014

35

A Novel Approach for Characterizing Protein Ligand Complexes: Molecular Basis for Specificity of Small-Molecule Bcl-2 Inhibitors

Lugovskoy, Alexey A., Degterev, Alexei I., Fahmy, Amr F., Zhou, Pei, Gross, John D., Yuan, Junying, Wagner, Gerhard

Journal:

Journal of the American Chemical Society

Year:

2002

Language:

english

File:

PDF, 396 KB

english, 2002

36

Role of Akt and mammalian target of rapamycin in functional outcome after concussive brain injury in mice

Zhu, Xiaoxia, Park, Juyeon, Golinski, Julianne, Qiu, Jianhua, Khuman, Jugta, Lee, Christopher CH, Lo, Eng H, Degterev, Alexei, Whalen, Michael J

Journal:

Journal of Cerebral Blood Flow and Metabolism

Year:

2014

Language:

english

File:

PDF, 661 KB

english, 2014

37

Optimization of the anti-cancer activity of the phosphatidylinositol-3 kinase pathway inhibitor PITENIN-1: switching thiourea with 1,2,3-triazole

Kommagalla, Yadagiri, Cornea, Sinziana, Riehle, Robert, Torchilin, Vladimir, Degterev, Alexei, Ramana, Chepuri V.

Journal:

Year:

2014

Language:

english

File:

PDF, 884 KB

english, 2014

38

[IEEE 2009 IEEE/NIH Life Science Systems and Applications Workshop (LiSSA) Formerly known as LSSA and - Bethesda, MD, USA (2009.04.9-2009.04.10)] 2009 IEEE/NIH Life Science Systems and Applications Workshop - An image based system biology approach for Alzheimer's disease pathway analysis

Yue Huang,, Zhou, Xiaobo, Benchun Miao,, Lipinski, Marta, Zheng Xia,, Guangshu Hu,, Degterev, Alexei, Junying Yuan,, Wong, Stephen T.C.

Year:

2009

Language:

english

File:

PDF, 283 KB

english, 2009

39

Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury

Degterev, Alexei, Huang, Zhihong, Boyce, Michael, Li, Yaqiao, Jagtap, Prakash, Mizushima, Noboru, Cuny, Gregory D, Mitchison, Timothy J, Moskowitz, Michael A, Yuan, Junying

Journal:

Nature Chemical Biology

Year:

2013

Language:

english

File:

PDF, 80 KB

english, 2013

40

In vitro cytotoxicity of novel pro-apoptotic agent DM-PIT-1 in PEG-PE-based micelles alone and in combination with TRAIL

Skidan, Igor, Miao, Benchun, Thekkedath, Ritesh V, Dholakia, Parita, Degterev, Alexei, Torchilin, Vladimir

Journal:

Year:

2009

Language:

english

File:

PDF, 743 KB

english, 2009

41

Combination therapy targeting Akt and mammalian target of rapamycin improves functional outcome after controlled cortical impact in mice

Park, Juyeon, Zhang, Jimmy, Qiu, Jianhua, Zhu, Xiaoxia, Degterev, Alexei, Lo, Eng H, Whalen, Michael J

Journal:

Journal of Cerebral Blood Flow and Metabolism

Year:

2012

Language:

english

File:

PDF, 617 KB

english, 2012

42

Cytotoxicity of PEGylated liposomes co-loaded with novel pro-apoptotic drug NCL-240 and the MEK inhibitor cobimetinib against colon carcinoma in vitro

Sriraman, Shravan Kumar, Geraldo, Vananelia, Luther, Ed, Degterev, Alexei, Torchilin, Vladimir

Journal:

Journal of Controlled Release

Year:

2015

Language:

english

File:

PDF, 1.27 MB

english, 2015

43

A Genome-Wide RNAi Screen Reveals Multiple Regulators of Caspase Activation

Caroline H. Yi, Dodzie K. Sogah, Michael Boyce, Alexei Degterev, Dana E. Christofferson and Junying Yuan

Journal:

The Journal of Cell Biology

Year:

2007

Language:

english

File:

PDF, 2.15 MB

english, 2007

44

Combination Nanopreparations of a Novel Proapoptotic Drug – NCL-240, TRAIL and siRNA

Riehle, Robert, Pattni, Bhushan, Jhaveri, Aditi, Kulkarni, Abhijit, Thakur, Ganesh, Degterev, Alexei, Torchilin, Vladimir

Journal:

Pharmaceutical Research

Year:

2016

Language:

english

File:

PDF, 1.43 MB

english, 2016

45

The Channel of Death

Alexei Degterev, Michael Boyce and Junying Yuan

Journal:

The Journal of Cell Biology

Year:

2001

Language:

english

File:

PDF, 984 KB

english, 2001

46

Targeting phospshatidylinositol 3-kinase signaling with novel phosphatidylinositol 3,4,5-triphosphate antagonists

Miao, Benchun, Degterev, Alexei

Journal:

Year:

2011

Language:

english

File:

PDF, 727 KB

english, 2011

47

Generation of small molecules to interfere with regulated necrosis

Degterev, Alexei, Linkermann, Andreas

Journal:

Cellular and Molecular Life Sciences

Year:

2016

Language:

english

File:

PDF, 652 KB

english, 2016

48

Targeting of Micelles and Liposomes Loaded with the Pro-Apoptotic Drug, NCL-240, into NCI/ADR-RES Cells in a 3D Spheroid Model

Pattni, Bhushan S., Nagelli, Srikar G., Aryasomayajula, Bhawani, Deshpande, Pranali P., Kulkarni, Abhijit, Hartner, William C., Thakur, Ganesh, Degterev, Alexei, Torchilin, Vladimir P.

Journal:

Pharmaceutical Research

Year:

2016

Language:

english

File:

PDF, 6.01 MB

english, 2016

49

Erratum to: Targeting of Micelles and Liposomes Loaded with the Pro-Apoptotic Drug, NCL-240, into NCI/ADR-RES Cells in a 3D Spheroid Model

Pattni, Bhushan S., Nagelli, Srikar G., Aryasomayajula, Bhawani, Deshpande, Pranali P., Kulkarni, Abhijit, Hartner, William C., Thakur, Ganesh, Degterev, Alexei, Torchilin, Vladimir P.

Journal:

Pharmaceutical Research

Year:

2016

Language:

english

File:

PDF, 212 KB

english, 2016

50

Complex Pathologic Roles of RIPK1 and RIPK3: Moving Beyond Necroptosis

Wegner, Kelby W., Saleh, Danish, Degterev, Alexei

Journal:

Trends in Pharmacological Sciences

Year:

2017

Language:

english

File:

PDF, 3.52 MB

english, 2017